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In an allergen-induced model of inflammatory colitis in mice, bilirubin has been shown to suppress inflammatory reactions by preventing the migration of leukocytes (especially eosinophil granulocytes) into the target tissue by interrupting cellular signalling that depends on the molecule vascular cell adhesion molecule-1 (VCAM-1) ( 61 )

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Witschi A, Reddy S, Stofer B, Lauterburg BH (1992)

Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals